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GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).

June 21, 2017

prudect name : GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2,…

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GDC-0994 is a potent, orally available ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively.

prudect name : GDC-0994 is a potent, orally available ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively.GDC-0994 Synonyms: CAS NO: 1453848-26-4Molecular Formula: C21H18ClFN6O2Molecular Weight: 440.86Purity: 98% minSolubility:…

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VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.

prudect name : VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.GIT 27; VGX 1027 Synonyms: CAS…

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Biological Activity Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 ¦ÌM respectively). Orally bioavailable.

prudect name : Biological Activity Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC,…

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5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide; RG 7421

prudect name : 5-(2-Fluoro-4-iodophenylamino)imidazo[1,5-a]pyridine-6-carboxylic acid N-(2-hydroxyethoxy)amide; RG 7421GDC 0623 Synonyms: GDC-0623CAS NO: 1168091-68-6Molecular Formula: C16H14FIN4O3Molecular Weight: 456.21Purity: 98% minSolubility: in DMSOStorage: -20oC BGB324 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1851822

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GLPG0634(filgotinib) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively

prudect name : GLPG0634(filgotinib) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectivelyGLPG0634(filgotinib) Synonyms: CAS…

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GW-6604;2-Phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridine

prudect name : GW-6604;2-Phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridineGW-6604 Synonyms: CAS NO: 452342-37-9Molecular Formula: C19H14N4Molecular Weight: 298.34126Purity: 98% minSolubility: in DMSOStorage: -20oC RG-7388 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18517923

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GSK525762 is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth.

prudect name : GSK525762 is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds…

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Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid

prudect name : Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acidGW 9508 Synonyms: CAS NO: 885101-89-3Molecular Formula: C22H21NO3Molecular Weight: 347.41Purity: 98% minSolubility: In DMSOStorage: -20°C TAK 242 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18517654

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4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

prudect name : 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONEGSK-3InhibitorI,TDZD-8;NP 01139 Synonyms: GSK-3InhibitorI,TDZD-8;NP 01139CAS NO: 327036-89-5Molecular Formula: C10H10N2O2SMolecular Weight: 222.26Purity: 98% minSolubility: In DMSOStorage: −20°C MDV 3100 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1851724

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