PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 ¦ÌM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).

 June 21, 2017

prudect name : PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 ¦ÌM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).PTC-209 Synonyms:…

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Chemical Name: (R)-¦Á-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide

prudect name : Chemical Name: (R)-¦Á-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamidePF 477736 Synonyms: CAS NO: 952021-60-2Molecular Formula: C22H25N7O2Molecular Weight: 419.48Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. The PDE10A enzyme is expressed primarily in the brain, mostly in the striatum, nucleus accumbens and olfactory tubercle, and is thought to be particularly important in regulating the activity of dopamine-sensitive medium spiny neurons in the striatum which are known to be targets of conventional antipsychotic agents. n the conditioned avoidance response assay (CAR), PF-2545920 was active with an ED50 of 1 mg/kg.

prudect name : PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. The PDE10A enzyme is expressed primarily in the brain, mostly in the striatum,…

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Biological Activity of PLX-4720: PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-RafV600E kinase compared with a broad spectrum of other kinases (IC50:B-Raf=160 nM, BRK=130 nM, other kinases >1000nM), and potent cytotoxic effects are also exclusive to cells bearing the V600E allele (GI50<1.7 ¦ÌM, while other wild cell GI50>10¦ÌM).

prudect name : Biological Activity of PLX-4720: PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in…

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PF-04217903 is an orally bioavailabe, small-molecule MET tyrosine kinase inhibitor with potential antineoplastic activity. PF-04217903 demonstrates exquisite kinase selectivity. Inhibition studies of the c-Met mutants show that PF-04217903 is more susceptible to oncogenic mutations that attenuate potency than PF-02341066.

prudect name : PF-04217903 is an orally bioavailabe, small-molecule MET tyrosine kinase inhibitor with potential antineoplastic activity. PF-04217903 demonstrates exquisite kinase selectivity. Inhibition studies of the c-Met mutants show that…

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PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4

prudect name : PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains…

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prudect name : Prasugrel metaboliteSynonyms: trans-R-138727CAS NO: 239466-74-1Molecular Formula: C18H20FNO3SMolecular Weight: 349.42Purity: 98% minSolubility: In

prudect name : Prasugrel metabolite Synonyms: trans-R-138727CAS NO: 239466-74-1Molecular Formula: C18H20FNO3SMolecular Weight: 349.42Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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Propyliminum for breast cancer.

prudect name : Propyliminum for breast cancer.Propyliminum Synonyms: CAS NO: 21416-67-1Molecular Formula: C11H16N4O4Molecular Weight: 268.26914Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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prudect name : Procarbazine hydrochlorideSynonyms: CAS NO: 366-70-1Molecular Formula: C12H19N3O.HClMolecular Weight: 257.76Purity: 99%Solubility: Storage: −20°C

prudect name : Procarbazine hydrochloride Synonyms: CAS NO: 366-70-1Molecular Formula: C12H19N3O.HClMolecular Weight: 257.76Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Pregabalin is a novel ¦Ã-aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels, reducing the release of neurotransmitters, mainly used for clinical treatment of peripheral neuropathic pain and limitations of adjuvant therapy Part of the seizures.

prudect name : Pregabalin is a novel ¦Ã-aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels, reducing the release of neurotransmitters, mainly used for clinical treatment of peripheral…

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