RU58841 is a potent topical anti-androgen drugs, originally developed by the French pharmaceutical firm Roussel.

June 21, 2017

prudect name : RU58841 is a potent topical anti-androgen drugs, originally developed by the French pharmaceutical firm Roussel.RU-58841 Synonyms: RU-58841CAS NO: 154992-24-2Molecular Formula: C17H18F3N3O3Molecular Weight: 369.34Purity: 98% minSolubility: In DMSOStorage:…

📌

0💬 read more

prudect name : RilpivirineSynonyms: CAS NO: 500287-72-9Molecular Formula: C22H18N6Molecular Weight: 366.42Purity: 98% minSolubility: In DMSOStorage:

prudect name : Rilpivirine Synonyms: CAS NO: 500287-72-9Molecular Formula: C22H18N6Molecular Weight: 366.42Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

📌

0💬 read more

Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Regorafenib (BAY 73-4506) binds to and inhibits VEGFR-2 and -3, and tumor cell signaling kinases (RET, KIT, PDGFR, and Raf), which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. Regorafenib (BAY 73-4506) shows potent, oral activity in a wide variety of preclinical xenograft models.

prudect name : Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor…

📌

0💬 read more

Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

prudect name : Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazoloneRo 3306 Synonyms: CAS NO: 872573-93-8Molecular Formula: C18H13N3OS2Molecular Weight: 351.45Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌

0💬 read more

Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. The radio-sensitization by Rucaparib is due to downstream inhibition of activation of NF-¦ÊB, and is independent of SSB repair inhibition. Rucaparib could target NF-¦ÊB activated by DNA damage and overcome toxicity observed with classical NF-¦ÊB inhibitors without compromising other vital inflammatory functions. Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 ¦ÌM in permeabilised D283Med cells.

prudect name : Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. The radio-sensitization by Rucaparib is…

📌

0💬 read more

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. It binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. This leads to reduced expression of the Notch transcriptional target gene Hes 1. RO4929097 does not block tumor cell proliferation or induce apoptosis but instead produces a less transformed, flattened, slower-growing phenotype.

prudect name : RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. It binds to GS and blocks activation of Notch receptors, which…

📌

0💬 read more

Retapamulin SB-275833 is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.

prudect name : Retapamulin SB-275833 is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.Retapamulin SB-275833 Synonyms: CAS…

📌

0💬 read more

Biological Activity of Roscovitine (Seliciclib): Roscovitine (Seliciclib) is a potent and selective inhibitor of cyclin-dependent kinases (cdks). This agent displays higher inhibitory potency and higher selectivity compared to olomoucine.Roscovitine inhibits p34 cdc2/cyclin B (IC50 = 0.65 µM), p33 cdk2/cyclin A(IC50 = 0.70 µM), p33 cdk2/cyclin E (IC50 = 0.70 µM), and p33 cdk2/p35(IC50 = 0.20 µM) by competing for the ATP binding domain of these kinases. Roscovitine exhibits very low sensitivity towards related kinases, such as erk1 and erk2 (IC50 = 34 µM and 14 µM, respectively)

prudect name : Biological Activity of Roscovitine (Seliciclib): Roscovitine (Seliciclib) is a potent and selective inhibitor of cyclin-dependent kinases (cdks). This agent displays higher inhibitory potency and higher selectivity compared…

📌

0💬 read more

Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Similarly to the Aurora kinase inhibitor VX-680, reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia but was significantly less toxic than VX-680 on cells from healthy donors. The crystal structure of the reversine-Aurora B kinase complex shows that reversine is a novel class of ATP-competitive Aurora kinase inhibitors. Reversine might be a useful agent in cancer chemotherapy.

prudect name : Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that…

📌

0💬 read more

Ramoplanin [USAN:INN]; A 16686; A 16686A; Antibiotic A 16686; Glycolipodepsi peptide antibiotic produced by actinoplanes species ATCC33076. Ramoplanin is a complex antibiotic consisting of a main component designated as ramoplanin A2 and a small amount of related substances, ramoplanin A1, A¡¯1, A¡¯2, A3, and A¡¯3; MDL 62,198; Antibiotic A 16686, 2-(((3alpha,5beta)-3-hydroxy-7,24-dioxocholan-24-yl)amino)-, (SP-4-2)-; Glycolipodepsi peptide antibiotic produced by actinoplanes species ATCC33076

prudect name : Ramoplanin [USAN:INN]; A 16686; A 16686A; Antibiotic A 16686; Glycolipodepsi peptide antibiotic produced by actinoplanes species ATCC33076. Ramoplanin is a complex antibiotic consisting of a main component…

📌

0💬 read more

VD/VDR- vd-vdr

Posts by VD/VDR- vd-vdr