YM155 is not sensitive to survivn gene promoter-driven luciferase reporter activity even at 30 ¦ÌM. YM155 significantly inhibits endogenous survivin expression in PC-3 and PPC-1 human HRPC cells with deficient p53 through transcriptional inhibition of the survivin gene promoter. On the contrary YM155 shows no sufficient effect on protein expression of c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, ¦Á-actin, and ¦Â-tubulin at 100 nM. YM155 indicates great apoptosis in human cancer cell lines including PC-3 and PPC-1 with a concomitant increase in caspase-3 activity. YM155 potently inhibits human cancer cell lines (mutated or truncated p53) including PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5 and A375 with IC50 from 2.3 to 11 nM, respectively.YM155 increases the sensitivity of NSCLC cells to ¦Ã-radiation. The combination of YM155 and ¦Ã-radiation increases both the number of apoptotic cells and the activity of caspase-3. YM155 delays the repair of radiation-induced double-strand breaks in nuclear DNA.

June 21, 2017

prudect name : YM155 is not sensitive to survivn gene promoter-driven luciferase reporter activity even at 30 ¦ÌM. YM155 significantly inhibits endogenous survivin expression in PC-3 and PPC-1 human HRPC cells with deficient p53 through transcriptional inhibition of the survivin gene promoter. On the contrary YM155 shows no sufficient effect on protein expression of c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, ¦Á-actin, and ¦Â-tubulin at 100 nM. YM155 indicates great apoptosis in human cancer cell lines including PC-3 and PPC-1 with a concomitant increase in caspase-3 activity. YM155 potently inhibits human cancer cell lines (mutated or truncated p53) including PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5 and A375 with IC50 from 2.3 to 11 nM, respectively.YM155 increases the sensitivity of NSCLC cells to ¦Ã-radiation. The combination of YM155 and ¦Ã-radiation increases both the number of apoptotic cells and the activity of caspase-3. YM155 delays the repair of radiation-induced double-strand breaks in nuclear DNA.
YM 155

Synonyms: CAS NO: 781661-94-7Molecular Formula: C₂₀H₁₉N₄O₃.BrMolecular Weight: 443.30Purity: 98% minSolubility: In DMSOStorage: -20°C

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