Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4¡À1.1, 28.1¡À3.4, 22.4¡À2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.

June 21, 2017

prudect name : Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4¡À1.1, 28.1¡À3.4, 22.4¡À2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.
Vincristine sulfate

Synonyms: CAS NO: 2068-78-2Molecular Formula: C₄₆H₅₆N₄O₁₀.H₂SO₄Molecular Weight: 923.04Purity: 99%Solubility: In DMSOStorage: −20°C 2 years

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