Treatment of a monolayer of P19 cells with 1 ¦ÌM TWS119 causes 30¨C40% cells to differentiate specifically into neuronal lineages based on counting of TuJ1 positive cells with correct neuronal morphology (up to 60% neuronal differentiation occurred through the standard EB formation protocol with concomitant TWS119 treatment). TWS119 tightly binds to GSK-3¦Â (K D = 126 nM) which is quantified by surface plasmon resonance (SPR) and further demonstrates an IC50 of 30 nM.

June 21, 2017

prudect name : Treatment of a monolayer of P19 cells with 1 ¦ÌM TWS119 causes 30¨C40% cells to differentiate specifically into neuronal lineages based on counting of TuJ1 positive cells with correct neuronal morphology (up to 60% neuronal differentiation occurred through the standard EB formation protocol with concomitant TWS119 treatment). TWS119 tightly binds to GSK-3¦Â (K D = 126 nM) which is quantified by surface plasmon resonance (SPR) and further demonstrates an IC50 of 30 nM.
TWS 119

Synonyms: CAS NO: 601514-19-6Molecular Formula: C₁₈H₁₄N₄O₂Molecular Weight: 318.33Purity: 98% minSolubility: In DMSOStorage: -20°C

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