T0901317 is a potent and selective agonist for both LXR¦Á and LXR¦Â, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol. 1 Repa, J.J., Turley, S.D., Lobaccaro, J.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524-1529 (2000).

June 21, 2017

prudect name : T0901317 is a potent and selective agonist for both LXR¦Á and LXR¦Â, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol. 1 Repa, J.J., Turley, S.D., Lobaccaro, J.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524-1529 (2000).
T 0901317

Synonyms: CAS NO: 293754-55-9Molecular Formula: C₁₇H₁₂F₉NO₃SMolecular Weight: 481.33Purity: 98% minSolubility: In DMSOStorage: -20°C

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