SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 inhibited the RK from heat-shocked HeLa cells and osmotically stressed PC12 cells or bacterially expressed CSBP-2 with an IC50 of 0.6 ¦ÌM. SB 203580-induced activation of c-Raf is independent of stress-activated protein kinase 2a/p38 inhibition.

June 21, 2017

prudect name : SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 inhibited the RK from heat-shocked HeLa cells and osmotically stressed PC12 cells or bacterially expressed CSBP-2 with an IC50 of 0.6 ¦ÌM.
SB 203580-induced activation of c-Raf is independent of stress-activated protein kinase 2a/p38 inhibition.
SB 203580,RWJ 64809,PB 203580

Synonyms: RWJ 64809, PB 203580CAS NO: 152121-47-6Molecular Formula: C₂₁H₁₆FN₃OSMolecular Weight: 377.43Purity: 98% minSolubility: In DMSOStorage: −20°C

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