R406 is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM. R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 was selective as assessed using a large panel of Syk-independent cell-based assays representing both specific and general signaling pathways. Consistent with Syk inhibition, oral administration of R406 to mice reduced immune complex-mediated inflammation in a reverse-passive Arthus reaction and two antibody-induced arthritis models.

June 21, 2017

prudect name : R406 is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM.
R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 was selective as assessed using a large panel of Syk-independent cell-based assays representing both specific and general signaling pathways. Consistent with Syk inhibition, oral administration of R406 to mice reduced immune complex-mediated inflammation in a reverse-passive Arthus reaction and two antibody-induced arthritis models.
R406

Synonyms: CAS NO: 841290-80-0Molecular Formula: C₂₂H₂₃FN₆O₅Molecular Weight: 470.459Purity: 99%Solubility: Storage: −20°C

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