RN486 is a Bruton¡¯s tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell-based assays in multiple cell types, blocking Fc¦Å receptor cross-linking-induced degranulation in mast cells (IC(50) = 2.9 nM), Fc¦Ã receptor engagement-mediated tumor necrosis factor ¦Á production in monocytes (IC(50) = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC(50) = 21.0 nM).

June 21, 2017

prudect name : RN486 is a Bruton¡¯s tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell-based assays in multiple cell types, blocking Fc¦Å receptor cross-linking-induced degranulation in mast cells (IC(50) = 2.9 nM), Fc¦Ã receptor engagement-mediated tumor necrosis factor ¦Á production in monocytes (IC(50) = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC(50) = 21.0 nM).
RN486

Synonyms: CAS NO: 1242156-23-5Molecular Formula: C₃₅H₃₅FN₆O₃Molecular Weight: 606.27547Purity: 98% minSolubility: In DMSOStorage: -20°C

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