PD 153035 shows a potent and selective inhibitory effect on tyrosine phosphorylation induced with EGF with IC50 of 15 nM and 14 nM in Swiss 3T3 fibroblast and A-431 human epidermoid carcinoma cells, respectively. PD153035 shows growth inhibitory effects in cultures of EGF receptor-overexpressing human cancer cell lines including A431, Difi, DU145, MDA-MB-468 and ME180 cells with IC50 of 0.22 ¦ÌM, 0.3¦ÌM, 0.4 ¦ÌM, 0.68 ¦ÌM and 0.95 ¦ÌM, respectively.

June 21, 2017

prudect name : PD 153035 shows a potent and selective inhibitory effect on tyrosine phosphorylation induced with EGF with IC50 of 15 nM and 14 nM in Swiss 3T3 fibroblast and A-431 human epidermoid carcinoma cells, respectively. PD153035 shows growth inhibitory effects in cultures of EGF receptor-overexpressing human cancer cell lines including A431, Difi, DU145, MDA-MB-468 and ME180 cells with IC50 of 0.22 ¦ÌM, 0.3¦ÌM, 0.4 ¦ÌM, 0.68 ¦ÌM and 0.95 ¦ÌM, respectively.
PD153035 HCl

Synonyms: CAS NO: 153436-54-5Molecular Formula: C₁₆H₁₄BrN₃O₂.HClMolecular Weight: 396.67Purity: 98% minSolubility: In DMSOStorage: −20°C

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