Palomid 529 (P529) is a novel potent antitumour PI3K/Akt/mTOR inhibitor with a GI50 of <35 ¦ÌM in the NCI-60 cell lines panel. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. Palomid 529 (P529) inhibits tumor growth, angiogenesis, and vascular permeability. However, Palomid 529 (P529) has the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. Palomid 529 (P529) inhibited both VEGF-driven (IC50 = 20 nM) and bFGF-driven (IC50 = 30 nM) endothelial cell proliferation and retained the ability to induce endothelial cell apoptosis. In addition, Palomid 529 (P529) significantly enhanced the antiproliferative effect of radiation in prostate cancer cells (PC-3).

June 21, 2017

prudect name : Palomid 529 (P529) is a novel potent antitumour PI3K/Akt/mTOR inhibitor with a GI50 of <35 ¦ÌM in the NCI-60 cell lines panel. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. Palomid 529 (P529) inhibits tumor growth, angiogenesis, and vascular permeability. However, Palomid 529 (P529) has the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. Palomid 529 (P529) inhibited both VEGF-driven (IC50 = 20 nM) and bFGF-driven (IC50 = 30 nM) endothelial cell proliferation and retained the ability to induce endothelial cell apoptosis. In addition, Palomid 529 (P529) significantly enhanced the antiproliferative effect of radiation in prostate cancer cells (PC-3).
Palomid 529

Synonyms: Palomid 529CAS NO: 914913-88-5Molecular Formula: C₂₄H₂₂O₆Molecular Weight: 406.43Purity: 98% minSolubility: In DMSOStorage: −20°C

web site: www.medchemexpress.com