PNU120596 is a potent and selective positive allosteric ¦Á7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 ¦ÌM. PNU120596 (PNU 120596, PNU-120596) has no detectable effect on ¦Á4¦Â2, ¦Á3¦Â4 and ¦Á9¦Á10 receptors. Discovered in a high-throughput screen, PNU120596 (PNU 120596, PNU-120596) enhanced agonist-evoked calcium flux mediated by an engineered variant of the human ¦Á7 nAChR. Electrophysiology studies demonstrated that PNU120596 (PNU 120596, PNU-120596) increased peak agonist-evoked currents mediated by wild-type receptors and also proved a pronounced prolongation of the triggered response in the continued presence of agonist.

June 21, 2017

prudect name : PNU120596 is a potent and selective positive allosteric ¦Á7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 ¦ÌM. PNU120596 (PNU 120596, PNU-120596) has no detectable effect on ¦Á4¦Â2, ¦Á3¦Â4 and ¦Á9¦Á10 receptors. Discovered in a high-throughput screen, PNU120596 (PNU 120596, PNU-120596) enhanced agonist-evoked calcium flux mediated by an engineered variant of the human ¦Á7 nAChR. Electrophysiology studies demonstrated that PNU120596 (PNU 120596, PNU-120596) increased peak agonist-evoked currents mediated by wild-type receptors and also proved a pronounced prolongation of the triggered response in the continued presence of agonist.
PNU120596

Synonyms: PNU-120596CAS NO: 501925-31-1Molecular Formula: C₁₃H₁₄ClN₃O₄Molecular Weight: 311.72Purity: 98% minSolubility: In DMSOStorage: −20°C

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