Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 ¦ÌM, 1.6 ¦ÌM, 1.8 ¦ÌM and 1.6 ¦ÌM, respectively. In addition, the Kd of Nocodazole for Abl(E255K) phosphorylated, Abl(T315I) phosphorylated, BRAF(V600E) and PI3K¦Ã is 0.12 ¦ÌM, 0.17 ¦ÌM, 1.1 ¦ÌM and 1.5 ¦ÌM, respectively. Nocodazole induces apoptosis in chronic lymphocytic leukemia cells. Nocodazole inhibits insulin-stimulated glucose transport. Nocodazole decreases apoptosis in some human colon carcinoma cells. Nocodazole impairs the morphology and directionality of migrating medial gan-glionic eminence cells.

June 21, 2017

prudect name : Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 ¦ÌM, 1.6 ¦ÌM, 1.8 ¦ÌM and 1.6 ¦ÌM, respectively. In addition, the Kd of Nocodazole for Abl(E255K) phosphorylated, Abl(T315I) phosphorylated, BRAF(V600E) and PI3K¦Ã is 0.12 ¦ÌM, 0.17 ¦ÌM, 1.1 ¦ÌM and 1.5 ¦ÌM, respectively. Nocodazole induces apoptosis in chronic lymphocytic leukemia cells. Nocodazole inhibits insulin-stimulated glucose transport. Nocodazole decreases apoptosis in some human colon carcinoma cells. Nocodazole impairs the morphology and directionality of migrating medial gan-glionic eminence cells.
Nocodazole

Synonyms: CAS NO: 31430-18-9Molecular Formula: C₁₄H₁₁N₃O₃SMolecular Weight: 301.32Purity: 98% minSolubility: in DMSOStorage: -20oC

web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535290