BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells. For Class I PI3K family, NVP-BEZ235 biochemical IC50 are 4nM against p110¦Á,75nM against p110¦Â,7nM against p110¦Ò,5nM against p110¦Ã. Quantification of S473-Akt and T308P-Akt levels by ELISA revealed that 50% reduction occurred at a compound concentration of 8.0 nmol/L and 30 nmol/L.

June 21, 2017

prudect name : BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells. For Class I PI3K family, NVP-BEZ235 biochemical IC50 are 4nM against p110¦Á,75nM against p110¦Â,7nM against p110¦Ò,5nM against p110¦Ã. Quantification of S473-Akt and T308P-Akt levels by ELISA revealed that 50% reduction occurred at a compound concentration of 8.0 nmol/L and 30 nmol/L.
NVP-BEZ 235

Synonyms: CAS NO: 915019-65-7Molecular Formula: C30H23N5OMolecular Weight: 469.54Purity: 98% minSolubility: In DMSOStorage: -20°C


web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18534629