MPEP is a selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5) with IC50 of 36 nM. MPEP is a significantly more potent antagonist derived by structural derivatization around SIB-1757 and SIB-1893. MPEP has no agonist or antagonist activities at the human mGlu1b receptor expressed in CHO-K1 cells at concentrations up to 30 ¦ÌM. When tested at group II and III receptors, MPEP does not show agonist or antagonist activity at 100 ¦ÌM on human mGlu2, -3, -4a, -7b, and -8a receptors nor at 10 ¦ÌM on the human mGlu6 receptor.

June 21, 2017

prudect name : MPEP is a selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5) with IC50 of 36 nM. MPEP is a significantly more potent antagonist derived by structural derivatization around SIB-1757 and SIB-1893. MPEP has no agonist or antagonist activities at the human mGlu1b receptor expressed in CHO-K1 cells at concentrations up to 30 ¦ÌM. When tested at group II and III receptors, MPEP does not show agonist or antagonist activity at 100 ¦ÌM on human mGlu2, -3, -4a, -7b, and -8a receptors nor at 10 ¦ÌM on the human mGlu6 receptor.
MPEP

Synonyms: CAS NO: 96206-92-7Molecular Formula: C14H11NMolecular Weight: 193.24Purity: 98% minSolubility: In DMSOStorage: −20°C


web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525459