MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50 of 0.1 and 1.2 ¦ÌM for the inhibition of proteasome and calpain, respectively. The Ki of MG132 is 4 nM. MG132 inhibits TNF-¦Á-induced NF-¦ÊB activation and I¦ÊB¦Á degradation with an IC50 of 3 µM and prevents ¦Â-secretase cleavage. MG132 induces neurite outgrowth in PC12 cells and has anticancer properties in vitro. MG132 reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis.

June 21, 2017

prudect name : MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50 of 0.1 and 1.2 ¦ÌM for the inhibition of proteasome and calpain, respectively. The Ki of MG132 is 4 nM. MG132 inhibits TNF-¦Á-induced NF-¦ÊB activation and I¦ÊB¦Á degradation with an IC50 of 3 µM and prevents ¦Â-secretase cleavage. MG132 induces neurite outgrowth in PC12 cells and has anticancer properties in vitro. MG132 reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis.
MG-132

Synonyms: CAS NO: 133407-82-6Molecular Formula: C₂₆H₄₁N₃O₅Molecular Weight: 475.62Purity: 98% minSolubility: In DMSOStorage: −20°C

web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525394