LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. (IC50 of 13 nM, 6 nM, and 2.45 ¦ÌM for wild type, G2019S mutant, and drug resistant A2016T mutant LRRK2, respectively, in an in vitro ATP-site competititon binding assay). LRRK2-IN-1 is useful in treatment of Parkinson¡¯s disease.

June 21, 2017

prudect name : LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. (IC50 of 13 nM, 6 nM, and 2.45 ¦ÌM for wild type, G2019S mutant, and drug resistant A2016T mutant LRRK2, respectively, in an in vitro ATP-site competititon binding assay). LRRK2-IN-1 is useful in treatment of Parkinson¡¯s disease.
LRRK2-IN-1

Synonyms: CAS NO: 1234480-84-2Molecular Formula: C₃₁H₃₈N₈O₃Molecular Weight: 570.7Purity: 98% minSolubility: In DMSOStorage: -20°C

web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524659