Linsitinib (OSI-906) is a potent, selective orally active inhibitor of the insulin-like growth factor-1 receptor (IGF-1R).Linsitinib (OSI-906) demonstrated robust anti-tumor activity in an IGF-1R dependent xenograft model when administered orally once a day at doses of 25 and 75 mg/kg. Linsitinib (OSI-906) not only slowed the growth of IGF-1R-dependent tumors, but also reduced proliferation and/or survival of a broad panel of tumor cell lines. Specifically, among a panel of 28 human tumor cell lines, Linsitinib (OSI-906) potently (EC50 < 400 nM) reduced growth of 15 cell lines representative of colorectal, NSCLC, pancreatic, breast and pediatric cancers. In addition to the single agent activity, simultaneous treatment with a low dose of Linsitinib (OSI-906) and Tarceva effectively blocked both AKT and MAP kinase pathways in human colorectal tumors, which resulted in a decrease in the size of pre-existing tumors which was better than the effect of either drug alone

June 21, 2017

prudect name : Linsitinib (OSI-906) is a potent, selective orally active inhibitor of the insulin-like growth factor-1 receptor (IGF-1R).Linsitinib (OSI-906) demonstrated robust anti-tumor activity in an IGF-1R dependent xenograft model when administered orally once a day at doses of 25 and 75 mg/kg. Linsitinib (OSI-906) not only slowed the growth of IGF-1R-dependent tumors, but also reduced proliferation and/or survival of a broad panel of tumor cell lines. Specifically, among a panel of 28 human tumor cell lines, Linsitinib (OSI-906) potently (EC50 < 400 nM) reduced growth of 15 cell lines representative of colorectal, NSCLC, pancreatic, breast and pediatric cancers. In addition to the single agent activity, simultaneous treatment with a low dose of Linsitinib (OSI-906) and Tarceva effectively blocked both AKT and MAP kinase pathways in human colorectal tumors, which resulted in a decrease in the size of pre-existing tumors which was better than the effect of either drug alone
Linsitinib OSI-906

Synonyms: OSI-906CAS NO: 867160-71-2Molecular Formula: C26H23N5OMolecular Weight: 421.49Purity: 95% min EE 98%Solubility: In DMSOStorage: −20°C


RO-4917838 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18523568