Ku-0063794 is a specific inhibitor of mTOR, which inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks at 1000-fold higher concentrations. Ku-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK. Ku-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. Ku-0063794 is a prototype of mTOR inhibitor AZD8055 currently in Phase I/II trial in Advance Solid Tumors, Lymphoma and Endometrial Carcinoma.

June 21, 2017

prudect name : Ku-0063794 is a specific inhibitor of mTOR, which inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks at 1000-fold higher concentrations. Ku-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK. Ku-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. Ku-0063794 is a prototype of mTOR inhibitor AZD8055 currently in Phase I/II trial in Advance Solid Tumors, Lymphoma and Endometrial Carcinoma.
ku0063794

Synonyms: CAS NO: 938440-64-3Molecular Formula: C₂₅H₃₁N₅O₄Molecular Weight: 465.54Purity: 98% minSolubility: In DMSOStorage: −20°C

PF 03084014 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1852208