KU-55933 is a potent ATM inhibitor with an IC50 and a Ki of 13 and 2.2 nM, respectively. KU-55933 shows specificity with respect to inhibition of other phosphatidylinositol 3-kinase¨Clike kinases. Exposure of cells to KU-55933 resulted in a significant sensitization to the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin. Derivatives of this molecule may serve as novel radio- and chemosensitizors in clinical settings.

June 21, 2017

prudect name : KU-55933 is a potent ATM inhibitor with an IC50 and a Ki of 13 and 2.2 nM, respectively. KU-55933 shows specificity with respect to inhibition of other phosphatidylinositol 3-kinase¨Clike kinases. Exposure of cells to KU-55933 resulted in a significant sensitization to the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin. Derivatives of this molecule may serve as novel radio- and chemosensitizors in clinical settings.
KU-55933

Synonyms: CAS NO: 587871-26-9Molecular Formula: C₂₁H₁₇NO₃S₂Molecular Weight: 395.49Purity: 98% minSolubility: In DMSOStorage: −20°C

IPI145 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521957