MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM).

June 21, 2017

prudect name : MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM).
Ixazomib (MLN-9708)

Synonyms: CAS NO: 1201902-80-8Molecular Formula: C₂₀H₂₃BCl₂N₂O₉Molecular Weight: 517.12Purity: 98% minSolubility: In DMSOStorage: -20 oC

FR900506 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1851997