IC-87114 is the first isoform-selective PI3K inhibitor. This quinazolinone purine inhibits p110¦Ä(IC50=0.13µM) at mid-nanomolar concentrations and shows 100¨C1000-fold selectivity over other class I PI3Ks (p110¦Á, p110¦Â and p110¦Ã ). The selectivity of IC87114 is remarkable given that the residues that line the ATP binding pocket of the class I PI3Ks are highly conserved.

June 21, 2017

prudect name : IC-87114 is the first isoform-selective PI3K inhibitor. This quinazolinone purine inhibits p110¦Ä(IC50=0.13µM) at mid-nanomolar concentrations and shows 100¨C1000-fold selectivity over other class I PI3Ks (p110¦Á, p110¦Â and p110¦Ã ). The selectivity of IC87114 is remarkable given that the residues that line the ATP binding pocket of the class I PI3Ks are highly conserved.
IC-87114

Synonyms: CAS NO: 371242-69-2Molecular Formula: C22H19N7OMolecular Weight: 397.43Purity: 98% minSolubility: In DMSOStorage: −20°C


TMC 207 References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18519796