HMN-214(a prodrug of HMN-176) is a potent PLK1 inhibitor (an average cell IC50 of 118 nM). HMN-214 is an oral stilbene derivative. HMN-176 interferes with PLK1, but does not appear to directly inhibit PLK1. Instead, it alters its spatial distribution, resulting in cell cycle arrest at the G2¨CM phase, with destruction of the spindle polar bodies followed by DNA fragmentation. Drug-resistant cell lines showed low crossresistance to HMN-176. In human tumor xenografts, there was a broad spectrum of antitumor activity. The antitumor activity of HMN-214 was equal or superior to that of clinically available agents, including cisplatin, doxorubicin, vincristine, and tegafur-uracil .

June 21, 2017

prudect name : HMN-214(a prodrug of HMN-176) is a potent PLK1 inhibitor (an average cell IC50 of 118 nM). HMN-214 is an oral stilbene derivative. HMN-176 interferes with PLK1, but does not appear to directly inhibit PLK1. Instead, it alters its spatial distribution, resulting in cell cycle arrest at the G2¨CM phase, with destruction of the spindle polar bodies followed by DNA fragmentation. Drug-resistant cell lines showed low crossresistance to HMN-176. In human tumor xenografts, there was a broad spectrum of antitumor activity. The antitumor activity of HMN-214 was equal or superior to that of clinically available agents, including cisplatin, doxorubicin, vincristine, and tegafur-uracil .
HMN-214

Synonyms: IVX-214CAS NO: 173529-46-9 Molecular Formula: C₂₂H₂₀N₂O₅SMolecular Weight: 424.47Purity: 98% minSolubility: In DMSOStorage: −20°C

BKM 120 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519168