Biological Activity Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 ¦ÌM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

June 21, 2017

prudect name : Biological Activity
Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 ¦ÌM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
HBX 41108

Synonyms: CAS NO: 924296-39-9Molecular Formula: C₁₃H₃ClN₄OMolecular Weight: 266.64Purity: 98% minSolubility: In DMSOStorage: -20°C

ROCK inhibitor References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519018