GSK1070916 selectively inhibits Aurora B and Aurora C with Ki of 0.38 nM and 1.5 nM over Aurora A with Ki of 490 nM. Inhibition of Aurora B and Aurora C is time-dependent, with an enzyme-inhibitor dissociation half-life of >480 min and 270 min respectively. In addition, GSK1070916 is also a competitive inhibitor with respect to ATP.

June 21, 2017

prudect name : GSK1070916 selectively inhibits Aurora B and Aurora C with Ki of 0.38 nM and 1.5 nM over Aurora A with Ki of 490 nM. Inhibition of Aurora B and Aurora C is time-dependent, with an enzyme-inhibitor dissociation half-life of >480 min and 270 min respectively. In addition, GSK1070916 is also a competitive inhibitor with respect to ATP.
GSK 1070916

Synonyms: CAS NO: 942918-07-2Molecular Formula: C₃₀H₃₃N₇OMolecular Weight: 507.63Purity: 98% minSolubility: In DMSOStorage: -20°C

MK 0773 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18516225