GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line .For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879).

June 21, 2017

prudect name : GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line .For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879).
GDC-0879

Synonyms: CAS NO: 905281-76-7Molecular Formula: C₁₉H₁₈N₄O₂Molecular Weight: 334.37Purity: 98% minSolubility: In DMSOStorage: −20°C

CP673451 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515350