FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 ¦ÌM.In HeLa Notch¦¤E-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid ¦Â. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.

June 21, 2017

prudect name : FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 ¦ÌM.In HeLa Notch¦¤E-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid ¦Â. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.
FLI-06

Synonyms: CAS NO: 313967-18-9Molecular Formula: C₂₅H₃₀N₂O₅Molecular Weight: 438.52Purity: 98% minSolubility: In DMSOStorage: -20¡æ

GANT-61 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515348