Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. It inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM.

June 21, 2017

prudect name : Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. It inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM.
Epoxomicin (BU-4061T)

Synonyms: CAS NO: 134381-21-8Molecular Formula: C₂₈H₅₀N₄O₇Molecular Weight: 554.72Purity: 98% minSolubility: In DMSOStorage: -20°C

AUY922 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18513840