DAPT (GSI-IX) is a ¦Ã-secretase inhibitor with IC50 of 0.12 and 0.2 ¦ÌM for total A¦Â and A¦Â42 levels, respectively. DAPT (GSI-IX; ¦Ã-Secretase inhibitor IX) causes a reduction in A¦Â40 and A¦Â42 levels in human primary neuronal cultures and in brain extract, cerebrospinal fluid and plasma in vivo. DAPT (GSI-IX; ¦Ã-Secretase inhibitor IX) does not affect APP¦Á and APP¦Â levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. As an inhibitor of ¦Ã-secretase, DAPT may be useful in the study of ¦Â-amyloid (A¦Â) formation. As an inhibitor of Notch, DAPT may advance studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). Other ¦Ã-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4

June 21, 2017

prudect name : DAPT (GSI-IX) is a ¦Ã-secretase inhibitor with IC50 of 0.12 and 0.2 ¦ÌM for total A¦Â and A¦Â42 levels, respectively. DAPT (GSI-IX; ¦Ã-Secretase inhibitor IX) causes a reduction in A¦Â40 and A¦Â42 levels in human primary neuronal cultures and in brain extract, cerebrospinal fluid and plasma in vivo. DAPT (GSI-IX; ¦Ã-Secretase inhibitor IX) does not affect APP¦Á and APP¦Â levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. As an inhibitor of ¦Ã-secretase, DAPT may be useful in the study of ¦Â-amyloid (A¦Â) formation. As an inhibitor of Notch, DAPT may advance studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). Other ¦Ã-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4
DAPT (GSI-IX)

Synonyms: GSI-IXCAS NO: 208255-80-5Molecular Formula: C₂₃H₂₆F₂N₂O₄Molecular Weight: 432.464Purity: 98% minSolubility: In DMSOStorage: −20°C

CK-2017357 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18510590