Biological Activity of CYC116: CYC116 is an orally bioavailable£¬small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. CYC116 has a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, it demonstrated antitumor activity in both solid tumors and hematological cancers.

June 21, 2017

prudect name : Biological Activity of CYC116:
CYC116 is an orally bioavailable£¬small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.
CYC116 has a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, it demonstrated antitumor activity in both solid tumors and hematological cancers.
CYC116

Synonyms: CAS NO: 693228-63-6Molecular Formula: C₁₈H₂₀N₆OSMolecular Weight: 368.46Purity: 98% minSolubility: In DMSOStorage: −20°C

GS-4997 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509115