CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 ¦ÌM. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase I (Pol I), the multi-protein complex that synthesizes rRNA, is activated widely in cancer. Thus, selective inhibitors of RNA PolI may offer a general therapeutic strategy to block cancer cell proliferation. CX-5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX-5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts.

June 21, 2017

prudect name : CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 ¦ÌM. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase I (Pol I), the multi-protein complex that synthesizes rRNA, is activated widely in cancer. Thus, selective inhibitors of RNA PolI may offer a general therapeutic strategy to block cancer cell proliferation. CX-5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX-5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts.
CX-5461

Synonyms: CAS NO: 1138549-36-6Molecular Formula: C₂₇H₂₇N₇O₂SMolecular Weight: 513.61Purity: 98%Solubility: In DMSOStorage: -20°C

AZD-3965 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505797