Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators.

June 21, 2017

prudect name : Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators.
bendamustine hydrochloride

Synonyms: CAS NO: 3543-75-7Molecular Formula: C₁₆H₂₂Cl₃N₃O₂Molecular Weight: 394.72Purity: 99%Solubility: Storage: −20°C 2 years

AP-26113 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505330