BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively. HER1 expression has been shown in as much as 80% to 90% of colon and non¨Csmall- cell lung cancer. HER2 gene amplification and overexpression of the protein have been shown to occur in f30% of all breast cancer. BMS-599626 was highly selective when tested against a broad panel of diverse protein kinases. BMS-599626 abrogated HER1and HER2 signaling. BMS-599626 inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC50 in the range of 0.24 to 1 ¦ÌM.

June 21, 2017

prudect name : BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively. HER1 expression has been shown in as much as 80% to 90% of colon and non¨Csmall- cell lung cancer. HER2 gene amplification and overexpression of the protein have been shown to occur in f30% of all breast cancer. BMS-599626 was highly selective when tested against a broad panel of diverse protein kinases. BMS-599626 abrogated HER1and HER2 signaling. BMS-599626 inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC50 in the range of 0.24 to 1 ¦ÌM.
BMS-599626

Synonyms: AC480CAS NO: 8173837-23-1Molecular Formula: C₂₇H₂₇FN₈O₃.HClMolecular Weight: 567.01Purity: 98% minSolubility: In DMSOStorage: -20¡æ

868540-17-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503263