Fucoidan

Additional information:
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities.|Product information|CAS Number: 9072-19-9|Molecular Weight: 256.27|Formula: C8H16O7S|Chemical Name: [(2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyloxan-3-yl]oxidanesulfonic acid|Smiles: CO[C@H]1[C@H](O)[C@H](OS(O)(=O)=O)[C@H](C)O[C@@H]1C|InChiKey: WZPKXSSMRAQGAC-DWOUCZDBSA-N|InChi: InChI=1S/C8H16O7S/c1-4-7(13-3)6(9)8(5(2)14-4)15-16(10,11)12/h4-9H,1-3H3,(H,10,11,12)/t4-,5+,6+,7-,8-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.AARS1 Protein, Mouse (sf9, His, solution) web |Shelf Life: ≥12 months if stored properly.Docetaxel Apoptosis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31643211 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae. Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64 mg/mL. Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress.|In Vivo:|Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis.|Products are for research use only. Not for human use.|