Trioxsalen

Additional information:
Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker.PMID:32401050 Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation.|Product information|CAS Number: 3902-71-4|Molecular Weight: 228.24|Formula: C14H12O3|Chemical Name: 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one|Smiles: CC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1|InChiKey: FMHHVULEAZTJMA-UHFFFAOYSA-N|InChi: InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 6.6 mg/mL (28.92 mM; Need ultrasonic and warming). H2O : 1 mg/mL (4.38 mM; ultrasonic and warming and heat to 80°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Trioxsalen (200 nM) plus 365 nm light produce DNA crosslinks but not breaks in mouse L1210 leukemia cells. Trioxsalen/UVA treatment of HaCaT keratinocytes induces NF-kappaB binding activity, and that this is a synergistic effect. Trioxsalen shows anti-inflammatory capacities in vitro.|In Vivo:|Trioxsalen induces dose-dependent depletion of ATPase-positive LCs, with a maximal depletion of 80%, in oral mucous membrane (OMM) with PUVA (UVA doses of 1-8 J/cm2) in rat.|Products are for research use only. Not for human use.|