Potent and selective tyrosine kinase (Trk) inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively; AZ-23 showed in vivo TrkA kinase inhibition and efficacy in mice following oral administration; having potential for therapeutic utility in neuroblastoma and multiple other cancer indications.

June 21, 2017

prudect name : Potent and selective tyrosine kinase (Trk) inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively; AZ-23 showed in vivo TrkA kinase inhibition and efficacy in mice following oral administration; having potential for therapeutic utility in neuroblastoma and multiple other cancer indications.
AZ 23

Synonyms: CAS NO: 915720-21-7Molecular Formula: C₁₇H₁₉ClFN₇OMolecular Weight: 391.83Purity: 98% minSolubility: In DMSOStorage: -20°C

1094-61-7 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499565