TP-238 hydrochloride

Additional information:
TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases.|Product information|CAS Number: 2415263-05-5|Molecular Weight: 495.04|Formula: C22H31ClN6O3S|Chemical Name: 6-4-[3-(dimethylamino)propoxy]phenyl-2-methanesulfonyl-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine hydrochloride|Smiles: Cl.CN(C)CCCOC1C=CC(=CC=1)C1=CC(NCCCN2C=CC=N2)=NC(=N1)S(C)(=O)=O|InChiKey: FHVADRKEPFRFFF-UHFFFAOYSA-N|InChi: InChI=1S/C22H30N6O3S.Quinidine Anti-infection ClH/c1-27(2)13-6-16-31-19-9-7-18(8-10-19)20-17-21(26-22(25-20)32(3,29)30)23-11-4-14-28-15-5-12-24-28;/h5,7-10,12,15,17H,4,6,11,13-14,16H2,1-3H3,(H,23,25,26);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Praziquantel Technical Information |Shelf Life: ≥12 months if stored properly.PMID:32969978 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF.|Products are for research use only. Not for human use.|