Tetrazine-SS-NHS

Additional information :
Specifications:|Chemical Formula: C19H20N6O5S2|Molecular Weight: 476.54|CAS: N/A|Purity: 93%|Physical Form: red solid|Solubility: DCM, THF, acetonitrile, DMF and DMSO|Storage at: -20 oC|Tetrazine-SS-NHS is a cleavable heterobifunctional linker containing a tetrazine moiety for inverse electron demand Diels-Alder cycloaddition reactions and a NHS activated ester.845264-92-8 web The tetrazine will react with strained alkenes such as trans-cyclooctene, norbornene and cyclopropene to yield a stable dihydropyridazine linkage. The extremely fast kinetics and selectivity enables the conjugation of two low abundance biopolymers in an aqueous and otherwise complex chemical environment.944396-07-0 custom synthesis This bioorthogonal reaction possesses excellent selectivity and biocompatibility such that the complimentary partners can react with each other within richly functionalized biological systems, in some cases, living organisms.PMID:31298504 Thus, tetrazine-TCO ligation has found numerous applications in fluorescent imaging, drug delivery, PET and SPECT imaging, radionuclide therapy, radiochemistry or drug target identification among several others.|Biocompatible – click reaction occurs efficiently under mild buffer conditions; requires no accessory reagents such as a copper catalyst or reducing agents (e.g. DTT)|Chemoselective – tetrazines and trans-cyclooctene groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency|Unprecedented kinetics – inverse-electron demand Diels-Alder chemistry is the fastest bioorthogonal ligation available|Cleavable SS bond – can be cleaved with DTT, GSH or TCEP