Activation of excitatory receptors coupled to G-proteins can cause contraction of smooth muscle by increasing Ca2+-sensitivity without changing [Ca2+]. This pathway involves RhoA, a small, monomeric G-protein that activates Rho-kinase. Contractions elicited with EFS were inhibited with Y-27632 (1 nM¨C300¦ÌM). The inhibition was partial (97.0¡À1.5% and 85.6¡À3.6% inhibition at 300¦ÌM) with an IC50 of 3.3¡À0.25¦ÌM and 2.8¡À0.2 ¦ÌM in human and rabbit tissues respectively . The IC50 value (concentration that inhibits 50% of the response) of Y-27632 was 1 ¡À 0.2 µmol/L for the inhibition of shape change by U46619

June 21, 2017

prudect name : Activation of excitatory receptors coupled to G-proteins can cause contraction of smooth muscle by increasing Ca2+-sensitivity without changing [Ca2+]. This pathway involves RhoA, a small, monomeric G-protein that activates Rho-kinase. Contractions elicited with EFS were inhibited with Y-27632 (1 nM¨C300¦ÌM). The inhibition was partial (97.0¡À1.5% and 85.6¡À3.6% inhibition at 300¦ÌM) with an IC50 of 3.3¡À0.25¦ÌM and 2.8¡À0.2 ¦ÌM in human and rabbit tissues respectively . The IC50 value (concentration that inhibits 50% of the response) of Y-27632 was 1 ¡À 0.2 µmol/L for the inhibition of shape change by U46619
Y27632

Synonyms: CAS NO: 146986-50-7Molecular Formula: C₁₄H₂₁N₃OMolecular Weight: 247.34Purity: 98% minSolubility: In DMSOStorage: -20¡æ

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