XL147 is a selective inhibitor of Class I PI3K isoforms. XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of PIP3 and activation of the PI3K signaling pathway.XL147 exhibits dose-dependent and sustained inhibition of PI3K signaling in multiple human tumor xenograft models when administered as a single agent. Administration of XL147 in combination with various targeted and chemotherapeutic agents results in enhanced anti-tumor activity in multiple xenograft models over that observed with the corresponding single agents.

June 21, 2017

prudect name : XL147 is a selective inhibitor of Class I PI3K isoforms. XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of PIP3 and activation of the PI3K signaling pathway.XL147 exhibits dose-dependent and sustained inhibition of PI3K signaling in multiple human tumor xenograft models when administered as a single agent. Administration of XL147 in combination with various targeted and chemotherapeutic agents results in enhanced anti-tumor activity in multiple xenograft models over that observed with the corresponding single agents.
XL 147

Synonyms: SAR245408CAS NO: 956958-53-5Molecular Formula: C₂₁H₁₆N₆O₂S₂Molecular Weight: 448.52Purity: 98% minSolubility: In DMSOStorage: −20°C

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