Biological Activity:JAK3 inhibitor (IC50 = 1.8 ¦ÌM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 ¦ÌM).

June 21, 2017

prudect name : Biological Activity:JAK3 inhibitor (IC50 = 1.8 ¦ÌM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 ¦ÌM).
WHIP-154

Synonyms: CAS NO: 211555-04-3Molecular Formula: C₁₆H₁₄BrN₃O₃Molecular Weight: 376.2Purity: 98% minSolubility: In DMSOStorage: −20°C

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