The activation of p38 MAPKs leads to gene transcription and translation, followed by an increase in production of inflammatory mediators, such as TNF¦Á, IL-1¦Â, cyclooxygenase (COX)-2, IL-6, IL-12 and IFN¦Ã , all of which have been demonstrated to play important roles in autoimmune diseases such as rheumatoid arthritis (RA) and/or cardiovascular diseases. In an ex vivo blood assay primed with LPS, VX-702 dose-dependently inhibited the production of IL-6, IL-1¦Â and TNF¦Á (IC50 = 59, 122 and 99 ng/ml, respectively)

June 21, 2017

prudect name : The activation of p38 MAPKs leads to gene transcription and translation, followed by an increase in production of inflammatory mediators, such as TNF¦Á, IL-1¦Â, cyclooxygenase (COX)-2, IL-6, IL-12 and IFN¦Ã , all of which have been demonstrated to play important roles in autoimmune diseases such as rheumatoid arthritis (RA) and/or cardiovascular diseases. In an ex vivo blood assay primed with LPS, VX-702 dose-dependently inhibited the production of IL-6, IL-1¦Â and TNF¦Á (IC50 = 59, 122 and 99 ng/ml, respectively)
VX702

Synonyms: CAS NO: 745833-23-2 479543-46-9Molecular Formula: C₁₉H₁₂F₄N₄O₂Molecular Weight: 404.32Purity: 98% minSolubility: In DMSOStorage: −20°C

web site: www.medchemexpress.com