Torcetrapib dose-dependently increases aldosterone release from H295R cells after either 24 or 48 h of treatment with an EC50 of approximately 80 nM, this effect is mediated by calcium channel as calcium channel blockers completely blocks torcetrapib-induced corticoid release and calcium increase. Torcetrapib (1 ¦ÌM) significantly increases the expression of steroidogenic gene, CYP11B2 and CYP11B1, in H295R cell lines.

June 21, 2017

prudect name : Torcetrapib dose-dependently increases aldosterone release from H295R cells after either 24 or 48 h of treatment with an EC50 of approximately 80 nM, this effect is mediated by calcium channel as calcium channel blockers completely blocks torcetrapib-induced corticoid release and calcium increase. Torcetrapib (1 ¦ÌM) significantly increases the expression of steroidogenic gene, CYP11B2 and CYP11B1, in H295R cell lines.
Torcetrapib (CP-529414)

Synonyms: CAS NO: 262352-17-0Molecular Formula: C₂₆H₂₅F₉N₂O₄Molecular Weight: 600.47Purity: 98% minSolubility: In DMSOStorage: -20°C

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