Biological Activity of Tipifarnib (Zarnestra): Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor with an IC50 of 0.6 nM. It is a nonpeptidomimetic quinolinone with potential antineoplastic activity. It binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, it prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis

June 21, 2017

prudect name : Biological Activity of Tipifarnib (Zarnestra):
Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor with an IC50 of 0.6 nM. It is a nonpeptidomimetic quinolinone with potential antineoplastic activity. It binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, it prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis
Tipifarnib (Zarnestra)

Synonyms: IND 58359, R115777CAS NO: 192185-72-1Molecular Formula: C₂₇H₂₂Cl₂N₄OMolecular Weight: 489.4Purity: 98% minSolubility: In DMSOStorage: −20°C

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