Tafluprost ethyl amide is derived from 17-phenyl trinor Prostaglandin F2¦Á(17-phenyl trinor PGF2¦Á). A number of 17-phenyl trinor PGF2¦Á derivatives have been approved for the treatment of glaucoma.1,2,3,4 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.5 Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile.6 Tafluprost is a 2-series, 16-phenoxy analog of PGF2¦Á with the 15,15-difluoro substitution. As a free acid, Tafluprost is a very potent FP receptor agonist (Ki = 0.4 nM).6 Ethyl amides of PGs tend to increase lipid solubility, to improve uptake into tissues and to further lower the effective concentration

June 21, 2017

prudect name : Tafluprost ethyl amide is derived from 17-phenyl trinor Prostaglandin F2¦Á(17-phenyl trinor PGF2¦Á). A number of 17-phenyl trinor PGF2¦Á derivatives have been approved for the treatment of glaucoma.1,2,3,4 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.5 Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile.6 Tafluprost is a 2-series, 16-phenoxy analog of PGF2¦Á with the 15,15-difluoro substitution. As a free acid, Tafluprost is a very potent FP receptor agonist (Ki = 0.4 nM).6 Ethyl amides of PGs tend to increase lipid solubility, to improve uptake into tissues and to further lower the effective concentration
Tafluprost ethyl amide

Synonyms: CAS NO: 1185851-52-8Molecular Formula: C₂₄H₃₃F₂NO₄Molecular Weight: 437.5Purity: 99% minSolubility: Storage: -20°C

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