TPCA-1 is potent, selective inhibitor of I¦ÊB kinase-2 (IKK-2) (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-¦ÊB nuclear localization. TPCA-1 reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.

June 21, 2017

prudect name : TPCA-1 is potent, selective inhibitor of I¦ÊB kinase-2 (IKK-2) (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-¦ÊB nuclear localization. TPCA-1 reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.
TPCA-1

Synonyms: CAS NO: 507475-17-4Molecular Formula: C₁₂H₁₀FN₃O₂S Molecular Weight: 279.29Purity: 98% minSolubility: In DMSOStorage: −20°C

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