Semagacestat (LY450139) is a ¦Ã-secretase blocker with an IC50 of 15 nM.¦Â-amyloid is a peptide of 39 to 43 amino acids.The isoforms with 40 and 42 amino acids (A¦Â40/42) are the main constituents of amyloid plaques in the brains of Alzheimer¡¯s disease patients. ¦Â-amyloid is formed by proteolysis of APP. Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer¡¯s. Semagacestat blocks the enzyme ¦Ã-secretase, which (along with ¦Â-secretase) is responsible for APP proteolysis.

June 21, 2017

prudect name : Semagacestat (LY450139) is a ¦Ã-secretase blocker with an IC50 of 15 nM.¦Â-amyloid is a peptide of 39 to 43 amino acids.The isoforms with 40 and 42 amino acids (A¦Â40/42) are the main constituents of amyloid plaques in the brains of Alzheimer¡¯s disease patients. ¦Â-amyloid is formed by proteolysis of APP. Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer¡¯s. Semagacestat blocks the enzyme ¦Ã-secretase, which (along with ¦Â-secretase) is responsible for APP proteolysis.
Semagacestat (LY450139)

Synonyms: Semagacestat (LY450139)CAS NO: 425386-60-3Molecular Formula: C₁₉H₂₇N₃O₄Molecular Weight: 361.44Purity: 98% minSolubility: In DMSOStorage: −20°C

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