SNX-2112 is a potent synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 ¦ÌM for K562 cells. The heat shock protein 90 (Hsp90) chaperone not only regulates the conformational maturation but also stables the structures of oncogenic kinases as well as transcription factors. SNX-2112 is an active metabolite of the compounds SNX-5542. SNX-2112 is rapidly transformed form SNX-5542 after administration. In a panel of tumor cell lines, SNX-2112 degraded HER2 and mutant epidermal growth factor receptor and inhibited extracellular signal-modulated kinase and Akt activation.SNX-2112 inducen a Rb-dependent G1 arrest with subsequent apoptosis. which accumulates in tumors relative to normal tissues.

June 21, 2017

prudect name : SNX-2112 is a potent synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 ¦ÌM for K562 cells. The heat shock protein 90 (Hsp90) chaperone not only regulates the conformational maturation but also stables the structures of oncogenic kinases as well as transcription factors. SNX-2112 is an active metabolite of the compounds SNX-5542. SNX-2112 is rapidly transformed form SNX-5542 after administration. In a panel of tumor cell lines, SNX-2112 degraded HER2 and mutant epidermal growth factor receptor and inhibited extracellular signal-modulated kinase and Akt activation.SNX-2112 inducen a Rb-dependent G1 arrest with subsequent apoptosis. which accumulates in tumors relative to normal tissues.
SNX-2112

Synonyms: CAS NO: 908112-43-6Molecular Formula: C₂₃H₂₇F₃N₄O₃Molecular Weight: 464.48Purity: 98% minSolubility: In DMSOStorage: −20°C

web site: www.medchemexpress.com