SB 525334 shows no inhibition in the enzymes ALK2, 3, and 6, with IC50 values > 10 ¦ÌM. SB 525334 blocks phosphorylation induced by TGF-¦Â1 and nuclear translocation of Smad2/3 in renal proximal tubule cells. SB 525334 also inhibits the increased mRNA expression levels of plasminogen activator inhibitor-1 (PAI-1) and procollagen ¦Á1(I) induced by TGF-¦Â1 in A498 renal epithelial carcinoma cells at 1 ¦ÌM).SB 525334 (1 ¦ÌM) attenuates the heightened sensitivity to TGF-¦Â1 exhibited by pulmonary artery smooth muscle cells (PASMCs) from patients with familial forms of idiopathic pulmonary arterial hypertension (PAH).

June 21, 2017

prudect name : SB 525334 shows no inhibition in the enzymes ALK2, 3, and 6, with IC50 values > 10 ¦ÌM. SB 525334 blocks phosphorylation induced by TGF-¦Â1 and nuclear translocation of Smad2/3 in renal proximal tubule cells. SB 525334 also inhibits the increased mRNA expression levels of plasminogen activator inhibitor-1 (PAI-1) and procollagen ¦Á1(I) induced by TGF-¦Â1 in A498 renal epithelial carcinoma cells at 1 ¦ÌM).SB 525334 (1 ¦ÌM) attenuates the heightened sensitivity to TGF-¦Â1 exhibited by pulmonary artery smooth muscle cells (PASMCs) from patients with familial forms of idiopathic pulmonary arterial hypertension (PAH).
SB 525334

Synonyms: CAS NO: 356559-20-1Molecular Formula: C21H21N5Molecular Weight: 343.42Purity: 98% minSolubility: in DMSOStorage: -20oC


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